分类： Bioenergy

Genomatica和Braskem通过生物学过程一步生产丁二烯

来源于 Chemicals-technology.com

Direct-biological-production-of-butadiene-565px-1

Genomatica和Braskem公司的一组科学家声明他们研发出了一种在实验室通过直接生物反应过程来生产丁二烯的工艺。

自从2015年六月，两家公司就开始在位于San Diego 和 Campinas的Genomatica创新中心进行实验室规模的丁二烯生产。

在2013年， 两家公司就合作开发用可再生原料生产丁二烯的商业应用工艺。

在研究计划执行过程中， 两家公司的研发团队成功在两升发酵器中培育出一种可以消化糖并将其转化为丁二烯的微生物。

Genomatica已经能够在理论上识别出60种用微生物制造丁二烯的生物学方法。

从这60种方法中选取了五种用于实验室验证。

这个研究计划能够进一步提高两家公司的研发技术水平。

Genomatica研发中心高级副总裁Nelson Barton说 “我们的联合团队充分利用Genomatica的整合生物工程平台的计算技术和高容量的克隆和筛选能力迅速完成了一个重要里程碑。”

“只要我们推进这一研究计划，我们合理的菌种设计方法应该能够快速的，可预测的放大和较好的经济性。”

丁二烯用于轮胎，电子设备，鞋业，塑料，沥青，建筑材料和纺织业的橡胶生产，可再生丁二烯有望降低工业生产的碳排放。

七月，Genomatica与美国公司Cargill合作开发可工业应用的可再生化学品。

基于我们的合作关系，两家公司都希望生产出低成本的碳氢化合物原料，同时为化工生产者，分销商和用户提供协同支持服务。

 本人知识有限，如有翻译不当之处，请指正。

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Genomatica and Braskem produce single step butadiene through biological process

中文版

From Chemicals-technology.com

Direct-biological-production-of-butadiene-565px-1

A group of scientists at Genomatica and Braskem have announced that they have produced butadiene through a direct, bio-based process in a lab.

The companies have been producing butadiene in lab scale since June 2015 at Genomatica’s innovation centre in San Diego and Campinas.

In 2013, both Genomatica and Braskem joined to develop a commercial process for on-purpose production of butadiene from renewable feedstocks.

During the course of their programme, the team at Genomatica and Braskem has successfully developed a microorganism that consumes sugar and converts it to butadiene at lab scale, in two-litre fermenters.

Genomatica has been able to recognise 60 possible biological pathways with which a microorganism can make butadiene, theoretically.

Out of those 60 pathways, five were selected for experimental confirmation.

The programme further helps to boost intellectual knowledge of Braskem and Genomatica.

Genomatica R&D senior vice-president Nelson Barton said: “Our joint team has made good use of Genomatica’s integrated bioengineering platform, including its computational techniques and high-throughput cloning and screening, to quickly hit a key milestone.

“Our ‘rational’ approach to strain design should enable faster, more predictable scale-up and better economics as we advance the programme.”

Butadiene is a used in the production of rubber for tires, electrical appliances, footwear, plastics, asphalt, building materials, and latex and a renewable butadiene expects to lower carbon footprint in the industrial output.

In July, Genomatica partnered with American company Cargill to develop renewable chemicals for industrial applications.

With the partnership, both the companies are expected to produce a cost-effective source of carbohydrate feedstocks, as well as co-location support services to chemical producers, distributors and users.

 

Image: Braskem and Genomatica have successfully achieved direct biological production of butadiene at lab scale. Photo: courtesy of Genomatica, Inc.

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